Catherine Denning-Jannace, PhD

Postdoctoral Research Scholar
Katherine Franz Laboratory
Duke University, Department of Chemistry
Email address: Catherine.denningjannace@duke.edu
Lab phone number: 919-660-1660
Twitter: @cdenningjannace

Research interests:
Catherine in interested in studying the role of transition metals at the host-pathogen interface. Specifically, she is interested in investigating the impact of azole drug stress on Candida albicans metallohomeostasis and the role of metals in the yeast-to-hyphae transition.

Personal interests: 
When not in the lab Catherine enjoys spending time with her husband, 2 year old sons Cole & Kai, and pups Sidewalc & Consequence. In her limited spare time she enjoys reading, listening to music, and streaming the latest podcasts.

Publications:

Geronimo, I., Denning, C. A., Heidary, D. K., Glazer, E. C., Payne, C. M. (2018) Molecular determinants of small molecule affinity and enzyme activity of a cytochrome P450BM3 variant. Biophysical Journal 115,1251-1263.

Denning, C. A.*, Zamora, A.*, Wachter, E., Nease, L. A., Heidary, D. K., Ruiz, J., Glazer, E. C. (2017) Ruthenium-containing P450 inhibitors for dual antitumor activity. Dalton Transactions 46,2165-2173. *Co-first authors.

Geronimo, I., Denning, C. A., Rogers, W. E., Othman, T., Huxford, T., Heidary, D. K., Glazer, E. C., Payne, C. M. (2016) Effect of mutation and substrate binding on the stability of cytochrome P450BM3 variants. Biochemistry 55, 3594-3606.